The list below is a selection of publications from the lab that reflect some of our interests and our collaborations.
Click here for all publications.

Coming soon!!

Ubhi T ,et al
(2024)
Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells
Nature Cancer

Brown GW
(2024)
The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences
bioRxiv 2024.01.15.575754
doi: 10.1101/2024.01.15.575754
Abstract | Full Text

Jiang YK, Medley EA, Brown GW
(2023)
Two independent DNA repair pathways cause mutagenesis in template switching deficient Saccharomyces cerevisiae
Genetics 225: iyad153
doi: 10.1093/genetics/iyad153
Abstract | Full Text

O'Brien S, Ubhi T, Wolf L, Gandhi K, Lin S, Chaudary N, Dhani NC, Milosevic M, Brown GW, Angers S
(2023)
FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe
Cancer Research Communications 3: 2596-2607
doi: 10.1158/2767-9764.CRC-23-0306
Abstract | Full Text

Ho B, Sanford EJ, Loll-Krippleber R, Torres NP, Smolka MB, Brown GW
(2023)
Mec1-independent activation of the Rad53 checkpoint kinase revealed by quantitative analysis of protein localization dynamics
Elife 12: e82483
doi: 10.7554/eLife.82483
Abstract | Full Text

Loll-Krippleber R, Sajtovich VA, Ferguson MW, Ho B, Burns AR, Payliss BJ, Bellissimo J, Peters S, Roy PJ, Wyatt HDM, Brown GW
(2022)
Development of a yeast whole-cell biocatalyst for MHET conversion into terephthalic acid and ethylene glycol
Microbial Cell Factories 21: 280.
doi: 10.1186/s12934-022-02007-9
Abstract | Full Text

Ho B, Loll-Krippleber R, Brown GW
(2022)
Yeast goes viral: probing SARS-CoV-2 biology using S. cerevisiae
Microbial Cell 9: 80-83.
doi: 10.15698/mic2022.04.774
Abstract | Full Text

Ohnuki S, Ogawa I, Itto-Nakama K, Lu F, Ranjan A, Kabbage M, Gebre AA, Yamashita M, Li SC, Yashiroda Y, Yoshida S, Usui T, Piotrowski JS, Andrews BJ, Boone C, Brown GW, Ralph J, Ohya Y
(2022)
High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds
npj Systems Biology and Applications 8: 3.
doi: 10.1038/s41540-022-00212-1
Abstract | Full Text

Galati E, Bosio MC, Novarina D, Chiara M, Bernini GM, Mozzarelli AM, García-Rubio ML, Gómez-González B, Aguilera A, Carzaniga T, Todisco M, Bellini T, Nava GM, Frigè G, Sertic S, Horner DS, Baryshnikova A, Manzari C, D'Erchia AM, Pesole G, Brown GW, Muzi-Falconi M, Lazzaro F
(2021)
VID22 counteracts G-quadruplex-induced genome instability
Nucleic Acids Research 49: 12785-12804.
doi: 10.1038/s41598-021-93875-5
Abstract | Full Text

Ayra-Plasencia J, Ramos-Pérez C, Santana-Sosa S, Quevedo O, Medina-Suárez S, Matos-Perdomo E, Zamora-Dorta M, Brown GW, Lisby M, Machín F
(2021)
Topoisomerase II deficiency leads to a postreplicative structural shift in all Saccharomyces cerevisiae chromosomes
Scientific Reports 11: 14940.
doi: 10.1038/s41598-021-93875-5
Abstract | Full Text

Berg MD, Zhu Y, Ruiz BY, Loll-Krippleber R, Isaacson J, San Luis BJ, Genereaux J, Boone C, Villén J, Brown GW, Brandl CJ
(2021)
The amino acid substitution affects cellular response to mistranslation
G3 (Bethesda) 11: jkab218.
doi: 10.1093/g3journal/jkab218
Abstract | Full Text

Brown GW, Andrews B
(2021)
Setting molecular traps in yeast for identification of anticancer drug targets
Proceedings of the National Academy of Sciences USA 118: e2105547118.
doi: 10.1073/pnas.2105547118
Abstract | Full Text

Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, Sanchez O, Berman HK, Brown GW, Affar EB, Chenevix-Trench G, Antoniou AC, Arrowsmith CH, Raught B, Pujana MA, Mekhail K, Hakem A, Hakem R
(2021)
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors
Journal of Clinical Investigation 131: e140105.
doi: 10.1172/JCI140105
Abstract | Full Text

Berg MD, Zhu Y, Isaacson J, Genereaux J, Loll-Krippleber R, Brown GW, Brandl CJ
(2020)
Chemical-Genetic Interactions with the Proline Analog L-Azetidine-2-Carboxylic Acid in Saccharomyces cerevisiae.
G3 (Bethesda) 10: 4335-4345.
doi: 10.1139/bcb-2020-0151
Abstract | Full Text

Tamayo-Orrego L, Gallo D, Racicot F, Bemmo A, Mohan S, Ho B, Salameh S, Hoang T, Jackson AP, Brown GW, Charron F
(2020)
Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma
Nature Cancer 1: 840-854.
doi: 10.1038/s43018-020-0094-7
Abstract | Full Text

Olivieri M, Cho T, Álvarez-Quilón A, Li K, Schellenberg MJ, Zimmermann M, Hustedt N, Rossi SE, Adam S, Melo H, Heijink AM, Sastre-Moreno G, Moatti N, Szilard RK, McEwan A, Ling AK, Serrano-Benitez A, Ubhi T, Feng S, Pawling J, Delgado-Sainz I, Ferguson MW, Dennis JW, Brown GW, Cortés-Ledesma F, Williams RS, Martin A, Xu D, Durocher D
(2020)
A Genetic Map of the Response to DNA Damage in Human Cells
Cell 182:481-496.e21.
doi: 10.1016/j.cell.2020.05.040.
Abstract | Full Text | Pre-print

Novarina D, Desai R, Vaisica JA, Ou J, Bellaoui M, Brown GW, Chang M
(2020)
A genome-wide screen for genes affecting spontaneous direct-repeat recombination in Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics 2020 Apr 7. pii: g3.401137.2020.
doi: 10.1534/g3.120.401137
Abstract | Full Text | Pre-print

Zhu Y, Berg MD, Yang P, Loll-Krippleber R, Brown GW, Brandl CJ
(2020)
Mistranslating tRNA identifies a deleterious S213P mutation in the Saccharomyces cerevisiae eco1-1 allele
Biochemistry and Cell Biology 98: 624-630.
doi: 10.1139/bcb-2020-0151
Abstract | Full Text

Gallo D and Brown GW
(2019)
Post-replication repair: Rad5/HLTF regulation, activity on undamaged templates, and relationship to cancer
Critical Reviews in Biochemistry and Molecular Biology 20: 1-32.
doi: 10.1080/10409238.2019.1651817
Abstract | Full Text

D'Orazio KN, Wu CC, Sinha N, Loll-Krippleber R, Brown GW, Green R
(2019)
The Endonuclease Cue2 Cleaves mRNAs at Stalled Ribosomes During No Go Decay
eLife 8: e49117.
doi: 10.7554/eLife.49117
Abstract | Full Text

Ubhi T and Brown GW
(2019)
Exploiting DNA Replication Stress for Cancer Treatment
Cancer Research 79: 1730-1739.
doi.org/10.1158/0008-5472.CAN-18-3631
Abstract | Full Text

Gallo D, Kim T, Szakal B, Saayman X, Narula A, Park Y, Branzei D, Zhang Z, Brown GW
(2019)
Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates
Molecular Cell 73: 900-914. doi.org/10.1016/j.molcel.2019.01.001
Abstract | Full Text

Sing TL, Hung MP, Ohnuki S, Suzuki G, San Luis BJ, McClain M, Unruh JR, Yu Z, Ou J, Marshall-Sheppard J, Huh WK, Costanzo M, Boone C, Ohya Y, Jaspersen SL, Brown GW (2018)
The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion
Journal of Cell Biology 217: 2445-2462.
doi: 10.1083/jcb.201709009
Abstract | Full Text

Diaz-Mejia JJ, Celaj A, Mellor JC, Cote A, Balint A, Ho B, Bansal P, Shaeri F, Gebbia M, Weile J, Verby M, Karkhanina A, Zhang Y, Wong C, Rich J, Prendergast D, Gupta G, Ozturk S, Durocher D, Brown GW, Roth FP (2018)
Mapping DNA damage-dependent genetic interactions in yeast via party mating and barcode fusion genetics
Molecular Systems Biology 14: e7985.
doi: 10.15252/msb.20177985
Abstract | Full Text

Becker JR, Gallo D, Leung W, Croissant T, Thu YM, Nguyen HD, Starr TK, Brown GW, Bielinsky AK
(2018)
Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner
Nucleic Acids Research 46: 5634-5650.
doi: 10.1093/nar/gky313
Abstract | Full Text

Kuzmin E, VanderSluis B, Wang W, Tan G, Deshpande R, Chen Y, Usaj M, Balint A, Mattiazzi Usaj M, van Leeuwen J, Koch EN, Pons C, Dagilis AJ, Pryszlak M, Wang JZY, Hanchard J, Riggi M, Xu K, Heydari H, San Luis BJ, Shuteriqi E, Zhu H, Van Dyk N, Sharifpoor S, Costanzo M, Loewith R, Caudy A, Bolnick D, Brown GW, Andrews BJ, Boone C, Myers CL
(2018)
Systematic analysis of complex genetic interactions
Science 360. pii: eaao1729.
doi: 10.1126/science.aao1729
Abstract | Full Text

Ho B, Baryshnikova, A, Brown GW (2018)
Unification of Protein Abundance Datasets Yields a Quantitative Saccharomyces cerevisiae Proteome
Cell Systems
doi.org/10.1016/j.cels.2017.12.004
Abstract | Full Text | Data set and R scripts | Preview in Cell Systems

Saayman X, Ramos-Pérez C, Brown GW (2018)
DNA Replication Profiling Using Deep Sequencing
Methods in Molecular Biology 1672: 195-207
doi: 10.1007/978-1-4939-7306-4_15.
Abstract | Full Text

Diaz-Mejia JJ, Mellor JC, Cote A, Balint A, Ho B,
Bansal P, Shaeri F, Gebbia M, Weile J, Verby M, Karkhanina A, Zhang Y, Wong C, Rich J, Prendergast D, Gupta G, Ozturk S, Durocher D, Brown GW, Roth FP (2017)
Mapping DNA damage-dependent genetic interactions in yeast via orgy mating and barcode fusion genetics
bioRxiv doi.org/10.1101/181750
Full Text

Loll-Krippleber R, Brown GW (2017)
P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance
Nature Communications 8: 558
Abstract | Full Text

Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C (2017)
Functional annotation of chemical libraries across diverse biological processes
Nature Chemical Biology 13: 982-993
Abstract | Full Text

Ramos-Pérez C, Ayra-Plasencia J, Matos-Perdomo E, Lisby M, Brown GW, Machín F (2017)
Genome-Scale Genetic Interactions and Cell Imaging Confirm Cytokinesis as Deleterious to Transient Topoisomerase II Deficiency in Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics pii: g3.300104.2017. doi: 10.1534/g3.117.300104
Abstract | Full Text

Wheaton K, Campuzano D, Ma W, Sheinis M, Ho B, Brown GW, Benchimol S (2017)
Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome
Molecular and Cellular Biology 37(14) pii: e00659-16. doi: 10.1128/MCB.00659-16
Abstract | Full Text

Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S (2017)
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Nature Communications 8: 14432
Abstract | Full Text

Ho B, Baryshnikova A, Brown GW (2017)
Comparative analysis of protein abundance studies to quantify the Saccharomyces cerevisiae proteome
bioRxiv doi: 10.1101/104919
Full Text

Styles EB, Founk KJ, Zamparo LA, Sing TL, Altintas D, Ribeyre C, Ribaud V, Rougemont J, Mayhew D, Costanzo M, Usaj M, Verster AJ, Koch EN, Novarina D, Graf M, Luke B, Muzi-Falconi M, Myers CL, Mitra RD, Shore D, Brown GW, Zhang Z, Boone C, Andrews BJ (2016)
Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci
Cell Systems 3: 264-277.e10
Abstract | Full Text

Abraham KJ, Chan JN, Salvi JS, Ho B, Hall A, Vidya E, Guo R, Killackey SA, Liu N, Lee JE, Brown GW, Mekhail K (2016)
Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids
Nucleic Acids Research 44: 8870-8884
Abstract | Full Text

Bonner JN, Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X (2016)
Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates
Cell Reports 16: 368-78
Abstract | Full Text

Yimit A., Kim T., Anand R., Meister S., Ou J., Haber J.E., Zhang Z., Brown G.W. (2016)
MTE1 Functions with MPH1 in Double-Strand Break Repair
Genetics 203: 147-157
Abstract | Full Text

Dibitetto D., Ferrari M., Rawal C.C., Balint A., Kim T., Zhang Z., Smolka M.B., Brown G.W., Marini F., Pellicioli A. (2016)
Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks
Nucleic Acids Research 44: 669-82
Abstract | Full Text

Tkáč J., Xu G., Adhikary H., Young J.T., Gallo D., Escribano-Díaz C., Krietsch J., Orthwein A., Munro M., Sol W., Al-Hakim A., Lin Z.Y., Jonkers J., Borst P., Brown G.W., Gingras A.C., Rottenberg S., Masson J.Y., Durocher D. (2016)
HELB Is a Feedback Inhibitor of DNA End ResectionMolecular Cell 61: 405-18
Abstract | Full Text

Yimit A., Kim T., Anand R., Meister S., Ou J., Haber J.E., Zhang Z., Brown G.W. (2015)
YGR042W/MTE1 Functions in Double-Strand Break Repair with MPH1
bioRxiv doi: 10.1101/032581
Full Text

Jablonowski C.M., Cussiol J.R., Oberly S., Yimit A., Balint A., Kim T., Zhang Z., Brown G.W., Smolka M.B. (2015)
Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase
Genetics 201: 937-49
Abstract | Full Text

Yimit A., Riffle M., Brown G.W. (2015)
Genetic regulation of Dna2 localization during the DNA damage response
G3: Genes, Genomes, Genetics 5: 1937-1944
Abstract | Full Text

Dunham M.J., Gartenberg, M.R., Brown G.W. (2015)
Methods in Yeast Genetics and Genomics
2015 Edition: A CSHL Course Manual
Available from Cold Spring Harbor Laboratory Press
or Amazon

Balint A., Kim T., Gallo D., Cussiol J.R., Bastos de Oliveira F.M., Yimit A, Ou J., Nakato R., Gurevich A., Shirahige K., Smolka M.B, Zhang Z., Brown G.W. (2015)
Assembly of Slx4 signaling complexes behind DNA replication forks
The EMBO Journal 34: 2182-2197
Abstract | Full Text

Chaillot J., Tebbji F., Remmal A., Boone C., Brown G.W., Bellaoui M., Sellam A. (2015)
The monoterpene carvacrol generates endoplasmic reticulum stress in the pathogenic fungus Candida albicans
Antimicrobial Agents and Chemotherapy 59: 4584-4592
Abstract | Full Text

Torres N.P., Brown G.W. (2015)
A high-throughput confocal fluorescence microscopy platform to study DNA replication stress in yeast cells
Methods in Molecular Biology 1300: 1-12
Abstract | Full Text

Cussiol J.R., Jablonowski C.M., Yimit A., Brown G.W., Smolka M.B. (2015)
Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions
EMBO Journal 34: 1704-1717
Abstract | Full Text

Grote D., Moison C., Duhamel S., Chagraoui J., Girard S., Yang J., Mayotte N., Coulombe Y., Masson J.Y., Brown G.W., Meloche S., Sauvageau G. (2015)
E4F1 Is a Master Regulator of CHK1-Mediated Functions
Cell Reports 11: 210-219
Abstract | Full Text

Hendry J.A., Tan G., Ou J., Boone C., Brown G.W. (2015)
Leveraging DNA Damage Response Signaling to Identify Yeast Genes Controlling Genome Stability
G3: Genes, Genomes, Genetics 5: 997-1006
Abstract | Full Text

Larin M., Gallo D., Tamblyn L., Yang J., Liao H., Sabat N., Brown G.W., McPherson J.P. (2014)
Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair
Nucleic Acids Research 42: 9807-9820
Abstract | Full Text

Coschi C.H., Ishak C.A., Gallo D., Marshall A., Talluri S., Wang J., Cecchini M.J., Martens A.L., Percy V., Welch I., Boutros P.C., Brown G.W., Dick F.A. (2014)
Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy
Cancer Discovery 4: 840-853
Abstract | Full Text

Lee A.Y., St Onge R.P., Proctor M.J., Wallace I.M., Nile A.H., Spagnuolo P.A., Jitkova Y., Gronda M., Wu Y., Kim M.K., Cheung-Ong K., Torres N.P., Spear E.D., Han M.K., Schlecht U., Suresh S., Duby G., Heisler L.E., Surendra A., Fung E., Urbanus M.L., Gebbia M., Lissina E., Miranda M., Chiang J.H., Aparicio A.M., Zeghouf M., Davis R.W., Cherfils J., Boutry M., Kaiser C.A., Cummins C.L., Trimble W.S., Brown G.W., Schimmer A.D., Bankaitis V.A., Nislow C., Bader G.D., Giaever G. (2014)
Mapping the cellular response to small molecules using chemogenomic fitness signatures
Science 344: 208-211
Abstract | Full Text

Jagannathan M., Nguyen T., Gallo D., Luthra N., Brown G.W., Saridakis V., Frappier L. (2014)
A Role for USP7 in DNA Replication
Molecular and Cellular Biology 34: 132-145
Abstract | Full Text

Xu D., Shen W., Guo R., Xue Y., Peng W., Sima J., Yang J., Sharov A., Srikantan S., Yang J., Fox D. 3rd, Qian Y., Martindale J.L., Piao Y., Machamer J., Joshi S.R., Mohanty S., Shaw A.C., Lloyd T.E., Brown G.W., Ko M.S., Gorospe M., Zou S., Wang W. (2013)
Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation
Nature Neuroscience 16: 1238-1247
Abstract | Full Text

Torres N.P., Lee A.Y., Giaever G., Nislow C., Brown G.W. (2013)
A high-throughput yeast assay identifies synergistic drug combinations
Assay and Drug Development Technologies 11: 299-307
Abstract | Full Text

Srikumar T., Lewicki M.C., Costanzo M., Tkach J.M., van Bakel H., Tsui K., Johnson E.S., Brown G.W., Andrews B.J., Boone C., Giaever G., Nislow C., Raught B. (2013)
Global analysis of SUMO chain function reveals multiple roles in chromatin regulation
Journal of Cell Biology 201: 145-163
Abstract | Full Text

Chambers A.L., Ormerod G., Durley S.C., Sing T.L., Brown G.W., Kent N.A., Downs J.A. (2012)
The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres
Genes & Development 26: 2590-2603
Abstract | Full Text

Cheung-Ong K., Song K.T., Ma Z., Shabtai D., Lee A.Y., Gallo D., Heisler L.E., Brown G.W., Bierbach U., Giaever G., Nislow C. (2012)
Comparative Chemogenomics To Examine the Mechanism of Action of DNA-Targeted Platinum-Acridine Anticancer Agents
ACS Chemical Biology 7: 1892-1901
Abstract | Full Text

Tkach J.M., Yimit A., Lee A.Y., Riffle M., Costanzo M., Jaschob D., Hendry J.A., Ou J., Moffat J., Boone C., Davis T.N., Nislow C., Brown G.W. (2012)
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress
Nature Cell Biology 14: 966-976
Abstract | Full Text | News and Views Article | Image Database @ Yeast Resource Center | Abundance data with Z-scores

Yang J., Bachrati C.Z., Hickson I.D., Brown G.W. (2012) BLM and RMI1 Alleviate RPA Inhibition of TopoIIIα Decatenase Activity.
PLoS ONE 7(7): e41208.
Abstract | Full Text

Cheng E., Vaisica J.A., Ou J., Baryshnikova A., Lu Y., Roth F.P., Brown G.W. (2012)
Genome Rearrangements Caused by Depletion of Essential DNA Replication Proteins in Saccharomyces cerevisiae.
Genetics 192:147-160
Abstract | Full Text | Issue Highlights

Yang J., O'Donnell L., Durocher D., Brown G.W. (2012)
RMI1 Promotes DNA Replication Fork Progression and Recovery from Replication Fork Stress.
Mol Cell Biol 32:3054-3064
Abstract | Full Text

Davidson M.B., Katou Y., Keszthelyi A., Sing T.L., Xia T., Ou J., Vaisica J.A., Thevakumaran N., Marjavaara L., Myers C.L., Chabes A., Shirahige K., Brown G.W. (2012)
Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype.
EMBO J 31:895-907
Abstract | Full Text

Bellay J., Atluri G., Sing T.L., Toufighi K., Costanzo M., Ribeiro P.S., Pandey G., Baller J., VanderSluis B., Michaut M., Han S., Kim P., Brown G.W., Andrews B.J., Boone C., Kumar V., Myers C.L. (2011)
Putting genetic interactions in context through a global modular decomposition.
Genome Res 21: 1375-1387
Abstract | Full Text

Vaisica J.A., Baryshnikova A., Costanzo M., Boone C., Brown G.W. (2011)
Mms1 and Mms22 Stabilize the Replisome During Replication Stress.
Mol Biol Cell 22: 2396-2408
Abstract | Full Text

Baryshnikova A., Costanzo M., Kim Y., Ding H., Koh J., Toufighi K., Youn J.Y., Ou J., San Luis B.J., Bandyopadhyay S., Hibbs M., Hess D., Gingras A.C., Bader G.D., Troyanskaya O.G., Brown G.W., Andrews B., Boone C., Myers C.L. (2010)
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale.
Nat Methods 7: 1017-24.
Abstract | Full Text

O'Donnell L., Panier S., Wildenhain J., Tkach J.M., Al-Hakim A., Landry M.C., Escribano-Diaz C., Szilard R.K., Young J.T., Munro M., Canny M.D., Kolas N.K., Zhang W., Harding S.M., Ylanko J., Mendez M., Mullin M., Sun T., Habermann B., Datti A., Bristow R.G., Gingras A.C., Tyers M.D., Brown G.W., Durocher D. (2010)
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.
Mol Cell 40: 619-31.
Abstract | Full Text

Berbenetz N., Nislow C., Brown G.W. (2010)
Diversity of Eukaryotic DNA Replication Origins Revealed by Genome-wide Analysis of Chromatin Structure.
PLoS Genetics 6: e1001092.
Abstract | Full Text

Yang J., Bachrati C.Z., Ou J., Hickson I.D., Brown G.W. (2010)
Human Topoisomerase IIIα Is a Single-stranded DNA Decatenase That Is Stimulated by BLM and RMI1.
J Biol Chem 285: 21426-36.
Abstract | Full Text

Dion B. and Brown G.W. (2009)
Comparative genome hybridization on tiling microarrays to detect aneuploidies in yeast.
Methods Mol Biol 548: 1-18.
Abstract | Full Text

Davidson M.B. and Brown G.W. (2009)
Dissecting the DNA damage response using functional genomics approaches in S. cerevisiae. DNA Repair 8: 1110-1117.
Abstract | Full Text

Yu L, Lopez A, Anaflous A, El Bali B, Hamal A, Ericson E., Heisler L.E., McQuibban A., Giaever G., Nislow C., Boone C., Brown G.W., Bellaoui M.(2008)
Chemical–Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells
PLoS Genetics 4: e1000284.
Abstract | Full Text

Nagai S., Dubrana K., Tsai-Pflugfelder M., Davidson M.B., Roberts T.M., Brown G.W., Varela E., Hediger F., Gasser S.M., Krogan N.J. (2008)
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase
Science 322: 597-602
Abstract | Full Text | Faculty of 1000 Evaluation

Xu D., Guo R., Sobeck A., Bachrati C.Z., Yang J., Enomoto T., Brown G.W., Hoatlin M.E., Hickson I.D., Wang W. (2008)
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability
Genes & Development 22: 2843-2855.
Abstract | Full Text | G & D Perspective

Davidson M.B. and Brown, G.W. (2008)
The N- and C-termini of Elg1 contribute to the maintenance of genome stability
DNA Repair 7: 1221-1232.
Abstract | Full Text

Duro, E., Vaisica, J.A., Brown, G.W., Rouse, J. (2008)
Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage
DNA Repair 7: 811-818.
Abstract | Full Text

Roberts, T.M., Waris Zaidi, I., Vaisica, J.A., Peter, M., Brown, G.W. (2008)
Regulation of Rtt107 Recruitment to Stalled DNA Replication Forks by the Cullin Rtt101 and the Rtt109 Acetyltransferase
Molecular Biology of the Cell 19: 171-180
Abstract | Full Text | Faculty of 1000 Evaluation

Xu, H., Boone, C., Brown, G. W. (2007)
Genetic Dissection of Parallel Sister Chromatid Cohesion Pathways
Genetics 176: 1417-1429
Abstract | Full Text

Collins, S.R., Miller, K.M., Maas, N.L., Roguev, A., Fillingham, J., Chu, C.S., Schuldiner, M., Gebbia, M., Recht, J., Shales, M., Ding, H., Xu, H., Han, J., Ingvarsdottir, K., Cheng, B., Andrews, B., Boone, C., Berger, S.L., Hieter, P., Zhang, Z., Brown, G.W., Ingles, C.J., Emili, A., Allis, C.D., Toczyski, D.P., Weissman, J.S., Greenblatt, J.F., Krogan, N.J. (2007)
Functional Dissection of Protein Complexes Involved in Yeast Chromosome Biology Using a Genetic Interaction Map
Nature 446: 806-810
Abstract | Full Text

Yu, L., Pena Castillo, L., Mnaimneh, S., Hughes, T. R., Brown, G. W. (2006)
A Survey of Essential Gene Function in the Yeast Cell Division Cycle
Molecular Biology of the Cell 17: 4736-4747
Abstract | Full Text | Complete data set

Wu, L., Bachrati, C. Z., Ou, J., Xu, C., Yin, J., Chang, M., Wang, W., Li, L., Brown, G. W., Hickson, I.D. (2006)
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates
Proc Natl Acad Sci U S A 103: 4068-4073
Abstract | Full Text

Zhang, C., Roberts, T. M., Yang, J., Desai, R., Brown,
G. W. (2006)
Suppression of Genomic Instability by SLX5 and SLX8 in Saccharomyces cerevisiae
DNA Repair 5: 336-46
Abstract | Full Text

Roberts, T. M., Kobor, M. S., Bastin-Shanower, S. A., Ii, M., Horte, S. A., Gin, J.W., Emili, A., Rine, J., Brill, S. J., Brown, G. W. (2006)
Slx4 Regulates DNA Damage Checkpoint-dependent Phosphorylation of the BRCT Domain Protein Rtt107/Esc4
Molecular Biology of the Cell 17: 539-548
Abstract | Full Text

Davierwala, A. P., Haynes, J., Li, Z., Brost, R. L., Robinson, M. D., Yu, L., Mnaimneh, S., Ding, H., Zh,u H., Chen, Y., Cheng, X., Brown, G. W., Boone, C., Andrews, B. J., Hughes, T. R. (2005)
The synthetic genetic interaction spectrum of essential genes
Nature Genetics 37: 1147-52
Abstract | Full Text

Chang, M., Bellaoui, M., Zhang, C., Desai, R., Morozov, P., Delgado-Cruzata, L., Rothstein, R., Freyer, G. A., Boone, C., and Brown, G.W. (2005)
RMI1/NCE4, a Suppressor of Genome Instability, Encodes a Member of the RecQ Helicase/Topo III Complex
EMBO Journal 24: 2024-2033
Abstract | Full Text

Suter, B., Tong, A., Chang, M., Yu, L., Brown, G.W., Boone, C., and Rine, J. (2004)
The Origin Recognition Complex Links Replication, Sister Chromatid Cohesion, and Transcriptional Silencing in Saccharomyces cerevisiae
Genetics 167: 579-591
Abstract | Full Text

Tong, A.H.Y., Lesage, G., Bader, G., Ding, H., Xu, H., Xin, X., Young, J., Berriz, G.F., Brost, R., Chang, M., Chen, Y., Cheng, X., Chua, G., Friesen, H., Goldberg, D.S, Haynes, J., Humphries, C., He, G., Hussein, S., Ke, L., Krogan, N., Li, Z., Levinson, J.N., Lu, H., Ménard, P., Munyana, C., Parsons, A., Ryan, O., Tonikan, R., Roberts, T., Sdicu, A., Shapiro, J., Sheikh, B., Suter, B., Wong, S.L., Zhang, L.V., Zhu, H., Burd, C.G., Munro, S., Sander, C., Rine, J., Greenblatt, J., Peter, M., Bretscher, A., Bell, G., Roth, F.P., Brown, G.W., Andrews, B., Bussey, H., Boone, C. (2004)
Genetic Interaction Networks: Large-scale Mapping of Synthetic Genetic Interactions in Yeast.
Science 303: 803-813
Abstract | Full Text | Commentary

Mayer, M. L., Pot, I., Chang, M., Xu, H., Aneliunas, V., Kwok, T., Newitt, R., Aebersold, R., Boone, C., Brown, G. W., and Hieter, P. (2004)
Identification of protein complexes required for sister chromatid cohesion.
Molecular Biology of the Cell 15: 1736-1745
Abstract | Full Text

Parsons, A. B., Brost, R., Ding, H., Li, Z., Zhang, C., Sheikh, B., Brown, G. W., Kane, P. M., Hughes, T. R., and Boone, C. (2004)
Chemical Genomics: Integration of Chemical-Genetic and Genetic Interaction Data Links Biologically Active Compounds to Cellular Pathways and Targets.
Nature Biotechnology 22: 62-69
Abstract | Full Text | Commentary

Duncker, B.P. & Brown, G.W.(2003)
Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts.
Mutation Resarch 532: 21-27
Abstract | Full Text

Bellaoui, M., Chang, M., Ou, J., Xu, H., Boone, C., and Brown, G. W. (2003)
Elg1 forms an alternative RFC complex important for DNA replication and genome integrity.
EMBO Journal 22: 4304-4313
Abstract | Full Text | Commentary in Curr. Biol.

Chang, M., Bellaoui, M., Boone, C., and Brown, G. W. (2002)
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.
Proc. Natl. Acad. Sci. USA 99: 16934-16939
Abstract | Full Text

Fung, A. D., Ou, J., Beuler, S., and Brown, G.W. (2002)
A conserved domain of S. pombe dfp1+ is uniquely required for chromosome stability following alkylation damage during S phase.
Molecular and Cellular Biology 22: 4477-90
Abstract | Full Text | Faculty of 1000 Evaluation

Brown, G. W. and Kelly, T. J. (2000)
Regulation of DNA Replication.
Annual Review of Biochemistry 69: 829-880
Abstract | Full Text